Traditional approaches fall short when attempting to buy down risk in an ever-changing environment. Conflicting requirements of speed, convenience and security battle with one another as organizations seek to embrace digital transformation. This whitepaper focuses on defense-in-depth, a framework that is at the heart of buying down risk. It shows how multiple layers of defense, starting at the edge and including runtime application self-protection, can mitigate even complex attacks while helping teams work faster and more efficiently.